Updated: Oct 20
Aging gracefully is a universal aspiration. However, the passage of time doesn't come without its companions—health concerns that can cast a shadow over our golden years. From the intricate tapestry of cardiovascular complexities to the enigmatic realm of neurodegenerative disorders like Alzheimer's, age often introduces us to a spectrum of ailments that share a common thread: inflammation.
In essence, inflammation serves as the body's vigilant guardian, responding to both internal and external signals that hint at potential harm. Yet, recent studies have unveiled a tantalizing secret—aging often ushers in a subtle, persistent state of low-grade inflammation even in the absence of overt triggers. This intriguing phenomenon has earned its moniker: "inflammaging."
However, inflammaging is no mere bystander; it wields significant influence over the origin and progression of an array of age-related diseases, casting a veil over our well-being.
The pursuit of unraveling the intricate mechanisms that underlie inflammaging holds the promise of new horizons. These insights could potentially unlock novel therapeutic avenues, marking a new chapter in how we combat the impact of inflammaging.
For those with a scientific inclination, a deeper understanding of inflammaging is provided in this article: https://www.sciencedirect.com/science/article/pii/S1043276023000577?via%3Dihub
As we journey toward healthier and more vibrant lives, comprehending inflammaging could well be the key to unearthing hidden potentials, mitigating its effects, and rewriting the narrative of aging.
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Domenico Praticò, MD, is the Scott Richards North Star Charitable Foundation Chair for Alzheimer’s Research, Professor and Director of the Alzheimer’s Center at Temple, and Professor of Pharmacology at the Lewis Katz School of Medicine at Temple University